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Network Medicine: Complex Systems in Human Disease and Therapeutics
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Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine’s unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.
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Product details
Hardcover: 448 pages
Publisher: Harvard University Press; 1 edition (February 1, 2017)
Language: English
ISBN-10: 0674436539
ISBN-13: 978-0674436534
Product Dimensions:
6.5 x 1.2 x 9.5 inches
Shipping Weight: 2.1 pounds (View shipping rates and policies)
Average Customer Review:
5.0 out of 5 stars
1 customer review
Amazon Best Sellers Rank:
#641,740 in Books (See Top 100 in Books)
Network Medicine provides an insightful introduction to the new frontier of medicine. As a layman, I readily admit that it was not a fast read for me. My goal was to understand the basics of genomic medicine so I can be a more informed board member of a venture philanthropy initiative, The Alpha-1 Project. This book added substantially to my knowledge base. Certainly, it is looks like we are at the cusp of new era of genomic medicine given the FDA approvals of the Gilead/Kite, Novartis and Spark therapies, and the potential for more gene therapy approvals in 2018/19. Network Medicine is the engine that is making these advances possible and this book should be read by all interested in the future of drug discovery and innovative new therapies.
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